Studies on direct compression of tablets X. Measurement of tablet surface area by permeametry
1985; Elsevier BV; Volume: 41; Issue: 1 Linguagem: Inglês
10.1016/0032-5910(85)85074-9
ISSN1873-328X
AutoresGöran Alderborn, M. Duberg, Christer Nyström,
Tópico(s)Protein purification and stability
ResumoA method for measuring the permeability of tablets was developed. The specific surface areas of the tablets were then deduced using the permeability equation corrected for slip flow. The method was tested on some experimental parameters which had only a minor effect on the tablet surface area. The effect of compaction pressure on tablet surface area, obtained using both a gas adsorption method and a permeametry technique, were then studied for sodium chloride and saccharose (fraction 212–250 μm). The two methods gave similar surface area-pressure curves up to 150 MPa, both substances showing increasing surface area with pressure but a faster increase for saccharose. The permeametry surface area curves continued to increase within the whole pressure range, while the gas adsorption surface area levelled out for saccharose and decreased at the highest pressures for sodium chloride.
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