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The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus

2009; American Society for Clinical Investigation; Volume: 119; Issue: 5 Linguagem: Inglês

10.1172/jci38010

1558-8238

Michael P. Cancro, David D’Cruz, Munther A. Khamashta,

Immune Cell Function and Interaction

SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE.