Gastric Mucosal Mast Cells in the Common Laboratory Animals and Man
1968; American Medical Association; Volume: 203; Issue: 9 Linguagem: Inglês
10.1001/jama.1968.03140090038010
ISSN1538-3598
Autores Tópico(s)Biochemical Analysis and Sensing Techniques
ResumoThe mast-cell content of the gastric corpus and antrum mucosa of the frog, mouse, rat, hamster, guinea pig, rabbit, cat, dog, and man was studied with an improved method which increases the specificity of the toluidine blue stain for mast cells. Great variability in the density and distribution of gastric mucosal mast cells was noted in the different species. There appears to be no relationship between the known sensitivity of the stomach of a given species to histamine stimulation and its mast-cell content. None of the species demonstrated a topographic association between mucosal mast cells and parietal cells. The notion that endogenous histamine released frommucosalmast cells ultimately causes acid secretion cannot be supported by our data. It is more likely that non-mast-cell histamine is the physiologically active agent.
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