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Three-year experience in the application of PDT in the treatment of lung cancer

1993; SPIE; Volume: 1616; Linguagem: Inglês

10.1117/12.136956

1996-756X

Dimitar Kostadinov, Emil Benov, Krassimir Mitchev, V. Vlasov, Giulio Jori,

Photodynamic Therapy Research Studies

During a 3 year period, 20 patients with morphologically proven squamous cell carcinoma of the trachea or bronchi have been treated by photoradiation therapy (PRT). A Bulgarian gold vapor laser and hematoporphyrin of `Jacopo Monico,' Italy were used. The photosensitizer was applied intravenously 24 - 48 h prior to PDT. The median realized energy dose was 410 J/cm 2 for each patient with a middle power of 180 mW. In 5 of all the cases we performed two sessions. The obtained therapeutic results are as follows: CR -- one case (5%), SR -- 10 cases (50%), NR -- 3 cases (15%). The median survival of the patients with advanced cancer was 13.3 months. At the end of 1990 three patients were alive. Our experience shows that PRT is a promising palliative method in cases of advanced carcinoma for the recanalization of airways.