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A facile pathway to synthesize diketopiperazine derivatives

2002; Elsevier BV; Volume: 43; Issue: 5 Linguagem: Inglês

10.1016/s0040-4039(01)02005-6

1873-3581

Dexin Wang, Mingtao Liang, Gui-Jie Tian, Hao Lin, Hongqiang Liu,

Microbial Natural Products and Biosynthesis

Eighteen diketopiperazines (DKPs) were synthesized in good yields by a solid-phase protocol. This synthesis reveals that the OPac linker between the peptidyl and resin support is favorable to DKP-ring formation and offers a facile and effective way to prepare diverse DKP libraries for combinatorial chemistry.