Produção Nacional
Revisado por pares
IMMUNOEXPRESSION OF p53 PROTEIN AND PROLIFERATING CELL NUCLEAR ANTIGEN IN PENILE CARCINOMA
2002; Lippincott Williams & Wilkins; Volume: 167; Issue: 1 Linguagem: Inglês
10.1016/s0022-5347(05)65389-x
ISSN1527-3792
AutoresAntônio Carlos Pereira Martins, Sandro M. Faria, Adauto José Cologna, Haylton Jorge Suaid, Sílvio Tucci,
Tópico(s)Urologic and reproductive health conditions
ResumoNo AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jan 2002IMMUNOEXPRESSION OF p53 PROTEIN AND PROLIFERATING CELL NUCLEAR ANTIGEN IN PENILE CARCINOMA ANTONIO C.P. MARTINS, SANDRO M. FARIA, ADAUTO J. COLOGNA, HAYLTON J. SUAID, and SILVIO TUCCI ANTONIO C.P. MARTINSANTONIO C.P. MARTINS , SANDRO M. FARIASANDRO M. FARIA , ADAUTO J. COLOGNAADAUTO J. COLOGNA , HAYLTON J. SUAIDHAYLTON J. SUAID , and SILVIO TUCCISILVIO TUCCI View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65389-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We examined p53 protein and proliferating cell nuclear antigen immunoexpression as prognostic factors to the outcome of squamous cell carcinoma of the penis in 50 patients. Materials and Methods: Penectomy and lymphadenectomy were performed in 14 patients with clinically positive nodes while 36 with cN0 disease were treated with penectomy and kept under surveillance that resulted in subsequent lymphadenectomy due to nodal relapse in 8. Of 21 patients with confirmed nodal metastases 18 died of disease. Immunohistochemical reactions were performed via the avidin-biotin-immunoperoxidase method and the results were compared with tumor pT stage, grade, nodal status and cause specific death. Results: In univariate analysis proliferating cell nuclear antigen staining showed association only with nodal metastasis (p = 0.04) while p53 staining exhibited correlation with tumor pT stage (p = 0.0005), grade (p = 0.02), lymphatic spread (p = 0.02) and cause specific survival (p = 0.003). Multivariate analysis showed that p53 immunoreactivity was the only factor with prognostic significance for disease progression and cause specific survival. Tumor pT stage, grade and proliferating cell nuclear antigen staining had no significance for nodal metastases and cause specific death. Conclusions: Proliferating cell nuclear antigen staining had no prognostic value for disease progression. Since p53 over expression was associated with tumor progression and cause specific death, perhaps it should be evaluated in staging and therapeutic planning for patients with squamous cell carcinoma of the penis. References 1 : Carcinoma of the penis: improved survival by early regional lymphadenectomy based on the histological grade and depth of invasion of the primary lesion. J Urol1995; 154: 1364. Link, Google Scholar 2 : Outcomes of initial surveillance of invasive squamous cell carcinoma of the penis and negative nodes. J Urol1996; 155: 1626. Link, Google Scholar 3 : Can regional lymph node involvement be predicted in patients with carcinoma of the penis?. Br J Urol1994; 73: 549. 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Link, Google Scholar From the Division of Urology, Department of Surgery, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByFerrandiz-Pulido C, Masferrer E, Toll A, Hernandez-Losa J, Mojal S, Pujol R, Ramon y Cajal S, de Torres I and Garcia-Patos V (2018) mTOR Signaling Pathway in Penile Squamous Cell Carcinoma: pmTOR and peIF4E Over Expression Correlate with Aggressive Tumor BehaviorJournal of Urology, VOL. 190, NO. 6, (2288-2295), Online publication date: 1-Dec-2013.Dai B, Ye D, Kong Y, Yao X, Zhang H and Shen Y (2018) Predicting Regional Lymph Node Metastasis in Chinese Patients With Penile Squamous Cell Carcinoma: The Role of Histopathological Classification, Tumor Stage and Depth of InvasionJournal of Urology, VOL. 176, NO. 4, (1431-1435), Online publication date: 1-Oct-2006. Volume 167Issue 1January 2002Page: 89-93 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordsprotein p53proliferating cell nuclear antigenpenile neoplasmscarcinoma, squamous cellMetricsAuthor Information ANTONIO C.P. MARTINS More articles by this author SANDRO M. FARIA More articles by this author ADAUTO J. COLOGNA More articles by this author HAYLTON J. SUAID More articles by this author SILVIO TUCCI More articles by this author Expand All Advertisement PDF DownloadLoading ...
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