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Minor Alkaloids From Guatteria dumetorum with Antileishmanial Activity

2006; Thieme Medical Publishers (Germany); Volume: 72; Issue: 03 Linguagem: Inglês

10.1055/s-2005-916179

1439-0221

Jhonny Correa, Carlos Ríos Deidán, Amparo del Rosario Castillo, Luz Romero, Eduardo Ortega-Barrı́a, Phyllis D. Coley, Thomas A. Kursar, María V. Heller, William H. Gerwick, Luis Cubilla‐Rios,

Plant Parasitism and Resistance

Nine known alkaloids [(+)-isodomesticine (1), (+)-norisodomesticine (2), (+)-nantenine (3), (+)-neolitsine (4), (+)-lirioferine (5), (+)-N-methyllaurotetanine (6), (+)-norlirioferine (7), (+)-isoboldine (8) and (+)-reticuline (9)] were isolated from young leaves of Guatteria dumetorum. Their structures were confirmed by NMR, mass and UV spectral analysis and by comparison to literature data. The growth inhibitory activity of each alkaloid was determined against the parasite Leishmania mexicana. Compounds 1 - 4 all showed significant activity whereby potency increased when a methylenedioxy functionality was present, especially at the 1,2-positions.