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SYNTHESIS AND CHARACTERIZATION OF NEW ANTITUMOR TRANS-R,R-, TRANS-S,S - AND CIS -1,2-DIAMINOCYCLOHEXANE PLATINUM (IV) COMPLEXES

1994; Taylor & Francis; Volume: 31; Issue: 2 Linguagem: Inglês

10.1080/00958979408024206

1029-0389

Salaam Al-Baker, Zahid H. Siddik, Abdul R. Khokhar,

Ferrocene Chemistry and Applications

Abstract A series of isomeric 1, 2-diaminocyclohexane platinum (IV) complexes of the type DACH-PtIV-trans(X)2 cis(Y) (where DACH = trans-R,R-, trans-S,S- or cis-1,2-diaminocyclohexane, X = chloro, bromo, acetato, or trifluoroacetato, and Y = dichloro, dibromo, 1,1-cyclobutanedicarboxylato, tartronato, ketomalonato, or methylmalonato) has been synthesized. The isomeric DACH-PtIV-trans(X)2 cis(Y) complexes were prepared by first oxidizing the corresponding DACH-dihaloplatinum(II) or DACH-dicarboxylato-platinum(II) [DACH-PtIIY] with hydrogen peroxide to DACH-PtIV-trans(OH)2Y, and then replacing the axial hydroxo groups with chloro, bromo, or monocarboxylato ligands. These complexes were characterized by elemental analysis, and infrared and nuclear magnetic resonance (195Pt{1H}) spectroscopic techniques. Key Words: Platinum1,2-diaminocyclohexaneisomercarboxylatesynthesis