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Discovery of Carboranes as Inducers of 20S Proteasome Activity

2010; Wiley; Volume: 5; Issue: 8 Linguagem: Inglês

10.1002/cmdc.201000112

1860-7187

Hyun Seung Ban, Hidemitsu Minegishi, Kazuki Shimizu, Minako Maruyama, Yuka Yasui, Hiroyuki Nakamura,

RNA modifications and cancer

ChemMedChemVolume 5, Issue 8 p. 1236-1241 Communication Discovery of Carboranes as Inducers of 20S Proteasome Activity Hyun Seung Ban Dr., Hyun Seung Ban Dr. Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this authorHidemitsu Minegishi, Hidemitsu Minegishi Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this authorKazuki Shimizu, Kazuki Shimizu Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this authorMinako Maruyama, Minako Maruyama Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this authorYuka Yasui, Yuka Yasui Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this authorHiroyuki Nakamura Prof. Dr., Hiroyuki Nakamura Prof. Dr. [email protected] Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this author Hyun Seung Ban Dr., Hyun Seung Ban Dr. Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this authorHidemitsu Minegishi, Hidemitsu Minegishi Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this authorKazuki Shimizu, Kazuki Shimizu Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this authorMinako Maruyama, Minako Maruyama Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this authorYuka Yasui, Yuka Yasui Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this authorHiroyuki Nakamura Prof. Dr., Hiroyuki Nakamura Prof. Dr. [email protected] Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo, 171-8588 (Japan), Fax: (+81) 3-5992-1029Search for more papers by this author First published: 23 July 2010 https://doi.org/10.1002/cmdc.201000112Citations: 17Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract The carborane framework gives analogues able to induce 20S proteasome activities. A series of ortho-carboranylphenoxy derivatives were synthesized as 20S proteasome agonists, and carborane derivatives 11 a and 11 b were found to be potent inducers of the β1 and β2 activities of the 20S proteasome. Since small-molecule proteasome activators have not been developed, the carboranes described here have potential as chemical probes for the investigation of proteasome-dependent degradation pathways. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. 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