HIV-1-associated nephropathy and response to highly-active antiretroviral therapy
1998; Elsevier BV; Volume: 352; Issue: 9130 Linguagem: Inglês
10.1016/s0140-6736(98)24037-2
ISSN1474-547X
AutoresRavinder K. Wali, Cinthia Drachenberg, John C. Papadimitriou, Susan Keay, Emilio Ramos,
Tópico(s)HIV/AIDS drug development and treatment
ResumoA 37-year-old African-American man with schizophrenia and bipolar disorder was admitted with psychotic symptoms after stopping his medications. Within 2 weeks of admission, his blood urea increased from 8 to 21 mmol/L and creatinine from 203 to 450 μmol/L. 3 weeks later his serum sodium was 135 mmol/L, potassium 6·7 mmol/L, chloride 109 mmol/L, bicarbonate 13 mmol/L, urea 32 mmol/L, and creatinine 770 μmol/L. Calculated creatinine clearance was 7 mL/min and he required haemodialysis. His blood pressure was 132/70 mm Hg, weight 77 kg, and height 162 cm. He had pharyngeal thrush, penile warts, and prominent jugular veins without peripheral oedema. His medications were olanzapine, haloperidol, sodium valproate, and lorazepam. Additional laboratory tests indicated a normal urinary sediment on microscopy, urinary protein 9·9 g/day with normal urine and serum immunoelectrophoresis. He had a mild normocytic, normochromic anaemia, with haemoglobin of 95 g/L, and a normal platelet count. Serum albumin was 14 g/L and total cholesterol 7·2 mmol/L. Tests for collagen diseases, vasculitic syndromes, or infection with hepatitis or herpes group viruses were negative, and complement levels were normal; these tests were repeated 6 weeks later and remained unchanged. HIV-1 antibodies were present on enzyme-linked immunosorbent assay and western blot. His CD4 lymphocyte count was 0·04·109/L and the CDS count 0·42·109/L. Serum HIV-1 RNA by branched chain DNA assay was 906 000 copies per mL. An ultrasound examination was remarkable for 13·5 cm kidneys with increased echogenicity. DEPARTMENT OF ERROREtruscan wombs—In this research letter, by G Baggieri (Sept 5, p 790), the end of the first sentence on the second paragraph should read "… written by Soranus of Ephesus in the second century AD". Full-Text PDF
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