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The retinoblastoma protein and cell cycle regulation

1992; Elsevier BV; Volume: 8; Issue: 5 Linguagem: Inglês

10.1016/0168-9525(92)90221-o

1362-4555

Paul A. Hamel, Brenda L. Gallie, Robert A. Phillips,

Corneal Surgery and Treatments

Although the precise function of the retinoblastoma gene product, p110RB1, remains unknown, recent data suggest that it plays a role in the control of cellular proliferation by regulating transcription of genes required for a cell to enter or stay in a quiescent or G0 state, or for progression through the G1 phase of the cell cycle. However, it is difficult to rationalize the expression of p110RB1 in a wide range of tissues with the fact that mutations in the RB1 gene initiate cancers in a limited number of tissues.