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Granulocyte Colony-Stimulating Factor and Neutrophil Alkaline Phosphatase

1989; American College of Physicians; Volume: 111; Issue: 1 Linguagem: Inglês

10.7326/0003-4819-111-1-91_1

1539-3704

Toshikazu Ushijima,

Blood disorders and treatments

Letters and Corrections1 July 1989Granulocyte Colony-Stimulating Factor and Neutrophil Alkaline PhosphataseToshikazu Ushijima, MD, Yoshiaki Ohbayashi, MD, Hiroshi Sato, MD, Akio Urabe, MDToshikazu Ushijima, MDSearch for more papers by this author, Yoshiaki Ohbayashi, MDSearch for more papers by this author, Hiroshi Sato, MDSearch for more papers by this author, Akio Urabe, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-1-91_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Neutrophil alkaline phosphatase activity sometimes decreases in patients with myelodysplastic syndromes, suggesting a reduced neutrophil function. The number of neutrophils varies in each case, but patients with myelodysplastic syndromes often have various kinds of infections that are probably related to impaired neutrophil function. Recently, recombinant human granulocyte colony-stimulating factor (rhG-CSF) has been produced in large quantities and has been tried as a clinical treatment (1). We have treated a patient with myelodysplastic syndrome by administering rhG-CSF and observed not only an increase in the number of neutrophils but also an increase in the neutrophil alkaline phosphatase score....References1. SouzaBooneGabrilove LTJ. Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science. 1986;232:61-5. CrossrefMedlineGoogle Scholar2. YuoKitagawaOkabe AST. Recombinant human granulocyte colony-stimulating factor repairs the abnormalities of neutrophils in patients with myelodysplastic syndromes and chronic myelogenous leukemia. Blood. 1987;70:404-11. CrossrefMedlineGoogle Scholar3. KobayashiOkabeOzawa YTK. Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor—a preliminary report. Am J Med. 1989;86:178-82. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kanto Teishin Hospital Tokyo Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySweet's syndrome during therapy with granulocyte colony-stimulating factor in a patient with aplastic anaemiaNeutrophil kinetics shortly after initial administration of recombinant human granulocyte colony-stimulating factor: Neutrophil alkaline phosphatase activitv as an endorrenous marker 1 July 1989Volume 111, Issue 1Page: 91-91KeywordsGranulocyte colony stimulating factorMyelodysplastic syndromesNeutrophilsPhosphatases Issue Published: 1 July 1989 PDF DownloadLoading ...