Base catalysed phosphate diester hydrolysis
2001; Royal Society of Chemistry; Issue: 14 Linguagem: Inglês
10.1039/b103317b
ISSN1364-548X
AutoresNicholas H. Williams, Paul Wyman,
Tópico(s)Metal complexes synthesis and properties
ResumoThe rate of attack of hydroxide on dialkyl phosphate diesters is far slower than previously estimated, allowing us to estimate the stability of the diester link in DNA and showing that ethylene phosphate is 1011 fold more reactive towards attack by hydroxide than an acyclic diester (1000 fold more than previously estimated).
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