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Aryl hydrocarbon hydroxylase inducibility and lymphoblast formation in lung cancer patients

1979; Wiley; Volume: 23; Issue: 3 Linguagem: Inglês

10.1002/ijc.2910230308

1097-0215

Rupi Prasad, Naresh Prasad, J.E. Harrell, John Thornby, John H. Liem, Philip T. Hudgins, Julian Tsuang,

Pharmacogenetics and Drug Metabolism

Abstract Aryl hydrocarbon hydroxylase (AHH) inducibility and lymphoblast formation were studied in lymphocytes from healthy control subjects and from lung cancer patients undergoing radiotherapy. The relationship between AHH inducibility and percentage lymphoblasts was statistically significant only for the pre‐treatment patients (r = 0.598; p<0.05). In the control group and in patients undergoing radiotherapy the correlation between AHH inducibility and lymphoblast formation was positive but statistically it was not significant. Our data do not suggest a linear relationship between AHH inducibility and lymphoblast formation.