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Unresolved Issues in the Role of Cyclooxygenase-2 in Normal Physiologic Processes and Disease

2000; American Medical Association; Volume: 160; Issue: 7 Linguagem: Inglês

10.1001/archinte.160.7.913

1538-3679

Peter E. Lipsky, Peter C. Brooks, Leslie J. Crofford, Raymond N. DuBois, David Graham, Lee S. Simon, Leo B. A. Van De Putte, Steven B. Abramson,

Pregnancy and Medication Impact

Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.