Syntheses of nephritogenoside and related compounds
1993; Elsevier BV; Volume: 243; Issue: 1 Linguagem: Inglês
10.1016/0008-6215(93)84082-h
ISSN1873-426X
AutoresTadahiro Takeda, Keisuke Kojima, Yukio Ogihara,
Tópico(s)Plant Toxicity and Pharmacological Properties
ResumoNephritogenoside has been prepared by coupling of the acyl azide derivative of a N-triglycosyl dipeptide, derived from the corresponding hydrazide derivative of O-(2,3,4,6-tetra-O-acetyl-α-d-glucopyranosyl)-(1 → 6)-O-(2,3,4-tri-O-acetyl-β-d-glucopyranosyl)-(1 → 6)-2,3-di-O-benzyl-1-N-[N-(tert-butoxycarbonyl)-l-aspart-1-oyl-( l-proline methyl ester)-4-oyl]-α-d-glucopyranosylamine, with a nonadecapeptide, followed by deprotection of the desired protected nephritogenoside. The N-triglycosyl pentapeptide also has been prepared as a model compound.
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