Voltar
Artigo Revisado por pares
BIBTEX RIS

Induction of cellular immunosuppression by the human papillomavirus type 16 E7 oncogenic protein

1999; Elsevier BV; Volume: 53; Issue: 7 Linguagem: Inglês

10.1016/s0753-3322(00)88505-4

ISSN

1950-6007

Autores

Hélène Le Buanec, A Lachgar, R. D'Anna, Jean‐François Zagury, B Bizzini, Jacky Bernard, D. Ittelé, Sophie Hallez, N. Giannouli, Arsène Burny, Daniel Zagury,

Tópico(s)

Immune Response and Inflammation

Resumo

The human papillomavirus type 16 (HPV-16) E7 oncogenic protein is found in the culture supernatant of SiHa cells, a cervical carcinoma cell line. Extracellular E7 protein, acting as a viral toxin in human immune cells, induces the overproduction of the immune suppressive IFNα cytokine by APCs, and inhibits the T-cell response to recall and allogenic antigens. These effects should be taken into account for the design of anti-human cervical carcinoma vaccines.

Referência(s)