Portal de Periódicos da CAPES

Iso combretastatins A versus Combretastatins A: The Forgotten iso CA-4 Isomer as a Highly Promising Cytotoxic and Antitubulin Agent

2009; American Chemical Society; Volume: 52; Issue: 14 Linguagem: Inglês

10.1021/jm900321u

1520-4804

Samir Messaoudi, Bret Tréguier, Abdallah Hamzé, Olivier Provot, Jean‐François Peyrat, Jordi Rodrigo de losada, Jianmiao Liu, Jérôme Bignon, Joanna Wdzieczak‐Bakala, Sylviane Thoret, Joëlle Dubois, Jean‐Daniel Brion, Mouâd Alami,

Glycosylation and Glycoproteins Research

Herein is reported a convergent synthesis of isocombretastatins A, a novel class of potent antitubulin agents. These compounds having a 1,1-diarylethylene scaffold constitute the simplest isomers of natural Z-combretastatins A that are easy to synthesize without need to control the Z-olefin geometry. The discovery of isoCA-4 with biological activities comparable to that of CA-4 represents a major progress in this field.