Portal de Periódicos da CAPES

Estrogen receptor alpha and risk for cognitive impairment in postmenopausal women

2006; Lippincott Williams & Wilkins; Volume: 16; Issue: 2 Linguagem: Inglês

10.1097/01.ypg.0000194445.27555.71

1473-5873

Line Olsen, Henrik Berg Rasmussen, Thomas Hansen, Yu Z. Bagger, László B. Tankó, Gerong Qin, Claus Christiansen, Thomas Werge,

Cancer-related cognitive impairment studies

The estrogen receptor α (ESR1) gene has been implicated in the process of cognitive impairment in elderly women. In a paired case–control study, we tested whether two ESR1 gene polymorphisms (the XbaI and PvuII sites) are risk factors for cognitive impairment as measured by the six-item Orientation-Memory-Concentration test in postmenopausal Danish women. Hormone replacement therapy, age and executive cognitive ability were examined as covariates for ESR1 gene effects on cognitive impairment. The XbaI polymorphism showed a marginal effect on cognitive abilities (P=0.054) when adjusted for executive cognitive ability. Using a dominant genetic model for the X allele, we found an elevated risk (executive cognitive ability adjusted P=0.033) for cognitive impairment. Hormone replacement therapy also had a borderline effect on cognitive ability (P=0.049) and this effect was reflected in executive cognitive ability. These data support that the ESR1 gene variants affect cognitive functioning in postmenopausal women.