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Use of Recreational Drug 1,3-Dimethylethylamine (DMAA) Associated With Cerebral Hemorrhage

2012; Elsevier BV; Volume: 60; Issue: 4 Linguagem: Inglês

10.1016/j.annemergmed.2012.04.008

1097-6760

Paul Gee, Cheryl Tallon, Neil Long, Grant Moore, Ronald Boet, Suzanne Jackson,

Acute Ischemic Stroke Management

Dimethylamylamine (DMAA) was a forgotten pharmaceutical that was patented in 1944 as a nasal decongestant. DMAA has recently gained popularity as a dietary supplement, with claims of effectiveness as an athletic performance enhancer and weight loss aid. It is also sold as a recreational stimulant drug. DMAA is a sympathomimetic and potent pressor agent. This report describes 3 cases of cerebral hemorrhage in adults after the use of DMAA. The status of this substance as a synthetic or naturally occurring compound is also discussed. Dimethylamylamine (DMAA) was a forgotten pharmaceutical that was patented in 1944 as a nasal decongestant. DMAA has recently gained popularity as a dietary supplement, with claims of effectiveness as an athletic performance enhancer and weight loss aid. It is also sold as a recreational stimulant drug. DMAA is a sympathomimetic and potent pressor agent. This report describes 3 cases of cerebral hemorrhage in adults after the use of DMAA. The status of this substance as a synthetic or naturally occurring compound is also discussed. Correction NoticeAnnals of Emergency MedicineVol. 61Issue 1PreviewIn the October 2012 issue, in the article by Gee et al (“Use of Recreational Drug 1,3-Dimethylethylamine (DMAA) Associated With Cerebral Hemorrhage”; pages 431-434), there was a typographic error in the title. “1,3-Dimethylethylamine (DMAA)” should have been “1,3 Dimethylamylamine (DMAA).” We regret this error. Full-Text PDF Pharmacokinetic Data Distinguish Abusive Versus Dietary Supplement Uses of 1,3-DimethylamylamineAnnals of Emergency MedicineVol. 61Issue 6Preview1,3-Dimethylamylamine (DMAA) is a central nervous system stimulant that can be synthesized and has been detected in small quantities in Pelargonium graveolens.1,2 Case studies of recreational DMAA use reported previously in Annals indicate acute vascular toxicity.3 DMAA-containing dietary supplement products, by virtue of their formulations and label instructions, may result in an order of magnitude lower DMAA consumption than DMAA “party pills,” which may contain 300 mg DMAA per pill. Authors of numerous clinical studies of DMAA in healthy adults4 (ingesting 30 to 60 mg DMAA/day) report transient increases in blood pressure but no toxic effects. Full-Text PDF