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Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex

2006; American Association for the Advancement of Science; Volume: 312; Issue: 5774 Linguagem: Inglês

10.1126/science.1125572

1095-9203

Francesca Sargolini, Marianne Fyhn, Torkel Hafting, Bruce L. McNaughton, Menno P. Witter, May‐Britt Moser, Edvard I Moser,

Sleep and Wakefulness Research

Grid cells in the medial entorhinal cortex (MEC) are part of an environment-independent spatial coordinate system. To determine how information about location, direction, and distance is integrated in the grid-cell network, we recorded from each principal cell layer of MEC in rats that explored two-dimensional environments. Whereas layer II was predominated by grid cells, grid cells colocalized with head-direction cells and conjunctive grid x head-direction cells in the deeper layers. All cell types were modulated by running speed. The conjunction of positional, directional, and translational information in a single MEC cell type may enable grid coordinates to be updated during self-motion-based navigation.