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BIBTEX RIS

Indole-3-carbinol attenuates the deleterious gestational effects of bisphenol A exposure on the prostate gland of male F1 rats

2013; Elsevier BV; Volume: 43; Linguagem: Inglês

10.1016/j.reprotox.2013.11.001

1873-1708

Joyce Zalotti Brandt, Lívia Teresa Ribeiro da Silveira, Tony Fernando Grassi, Janete Aparecida Anselmo-Franci, Wagner José Fávaro, Sérgio Luís Felisbino, Luı́s Fernando Barbisan, Wellerson Rodrigo Scarano,

Carcinogens and Genotoxicity Assessment

Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 μg/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate.