Portal de Periódicos da CAPES

HYPOTHALAMIC TUMOR AND PRECOCIOUS PUBERTY

1954; Oxford University Press; Volume: 14; Issue: 1 Linguagem: Inglês

10.1210/jcem-14-1-1

1945-7197

Thomas Morley,

Glioma Diagnosis and Treatment

THE association of precocious sexual development with a tumor of the X hypothalamus is so uncommon as to justify reporting this case. Case No. 186080. R.G.C., a boy aged 7½, was admitted to the Neurosurgical Unit, Manchester Royal Infirmary on April 24, 1950, with headaches, vomiting and abnormal development of the external genitalia. Until six months before admission he had been a normal boy both mentally and physically. His first symptom was headache, often accompanied by vomiting which, with remissions lasting up to a few weeks, continued until shortly before admission. Three months after the onset of headaches his parents first noticed that his external genitals were growing abnormally large and pubic hair was appearing. At no time did the boy show any sexual desire and he was not observed to masturbate. He continued at school and did well there. Shortly after the onset of headache the boy himself observed a tremor of both hands which, however, was no embarrassment to his activities. He was well-mannered and quiet. His “physiologic” age was betrayed by a certain lack of that lawlessness which is common in boys of 8 or thereabouts, and by a distinct preference for adult rather than juvenile company. He would talk about “my girl friend” in an open, matter-of-fact way; she was a neighbor's daughter of his own age, towards whom improper advances had not been made, and the parents of both children regarded the relationship without disapproval.