Portal de Periódicos da CAPES

Hydrogel Design of Experiments Methodology to Optimize Hydrogel for iPSC‐NPC Culture

2014; Wiley; Volume: 4; Issue: 4 Linguagem: Inglês

10.1002/adhm.201400410

2192-2659

Jonathan Lam, S. Thomas Carmichael, William E. Lowry, Tatiana Segura,

Cellular Mechanics and Interactions

Bioactive signals can be incorporated in hydrogels to direct encapsulated cell behavior. Design of experiments methodology methodically varies the signals systematically to determine the individual and combinatorial effects of each factor on cell activity. Using this approach enables the optimization of three ligands concentrations (RGD, YIGSR, IKVAV) for the survival and differentiation of neural progenitor cells. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.