No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease
2000; Elsevier BV; Volume: 285; Issue: 2 Linguagem: Inglês
10.1016/s0304-3940(00)01057-0
ISSN1872-7972
AutoresMatt Baker, Daniel Graff-Radford, Fabienne Wavrant DeVriéze, Caroline Graff, Ronald Petersen, Emre Kokmen, Bradley F. Boeve, Liisa Myllykangas, Tuomo Polvikoski, Raimo Sulkava, Auli Verkoniemmi, Pentti J. Tienari, Matti Haltia, John Hardy, Mike Hutton, Jordi Pèrez‐Tur,
Tópico(s)Neuroscience and Neuropharmacology Research
ResumoWe and others have previously identified two distinct haplotypes of the TAU gene in Caucasian populations. In this study, we have assessed whether these haplotypes show an association with Alzheimer's disease in a variety of populations. They do not. These data are consistent with the view that the involvement of TAU in Alzheimer's disease is a downstream event.
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