Effect of Somatostatin on Bethanechol-Stimulated Gastric Pepsin Secretion in Gastric Fistula Dogs
1985; Taylor & Francis; Volume: 20; Issue: 1 Linguagem: Inglês
10.3109/00365528509089638
ISSN1502-7708
AutoresLars Ladegaard, K. Bech, Ditte Caroline Andersen,
Tópico(s)Asthma and respiratory diseases
ResumoThe effect of somatostatin on pepsin secretion was determined in six dogs with gastric fistulas during stimulation with bethanechol. Somatostatin inhibited dose-dependently the stimulated pepsin secretion, with a dose of 0.3 micrograms/kg/h being 35% inhibitory during stimulation with bethanechol, 80 micrograms/kg/h. Continuous infusion of somatostatin for 3 h did not cause any signs of tachyphylaxis. Withdrawal of somatostatin produced a return to the control level. The dose-response kinetics with five doses of bethanechol with and without somatostatin showed inhibition of a noncompetitive type. The effects of somatostatin were not altered by using adrenergic, dopaminergic, or serotonergic blocking drugs.
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