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Silicon‐Based Building Blocks for One‐Step 18 F‐Radiolabeling of Peptides for PET Imaging

2008; Wiley; Volume: 47; Issue: 26 Linguagem: Inglês

10.1002/anie.200705854

1521-3773

Linjing Mu, Aileen Höhne, P. August Schubiger, Simon M. Ametamey, Keith Graham, John E. Cyr, Ludger M. Dinkelborg, Timo Stellfeld, Ananth Srinivasan, Ulrike Voigtmann, Ulrich Klar,

Chemical Synthesis and Analysis

Radio-controlled landing of F: The facile 18F labeling of biomolecules has been achieved under mild conditions by using a unique silicon-based one-step approach (see scheme). A di-tert-butylsilyl derivative with an aryl linker was attached to a tetrapeptide. The assembly shows a hydrolytic stability that appears to be within the range required for in vivo positron emission tomography (PET) imaging applications. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705854_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.