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High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

2010; Elsevier BV; Volume: 29; Issue: 3 Linguagem: Inglês

10.1016/j.vaccine.2010.10.080

1873-2518

Pamela Magistrado, Daniel T. R. Minja, Justin Doritchamou, Nicaise Tuikue Ndam, Davis John, Christentze Schmiegelow, Achille Massougbodji, Madeleine Dahlbäck, Sisse Bolm Ditlev, Vera V. Pinto, Mafalda Resende, John Lusingu, Thor G. Theander, Ali Salanti, Morten A. Nielsen,

Hepatitis C virus research

Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4ɛ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4ɛ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.