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Novel DNA‐Damaging Tropolone Derivatives from Goupia glabra

2003; Wiley; Volume: 2003; Issue: 21 Linguagem: Inglês

10.1002/ejoc.200300284

1434-193X

Dulce Mesa‐Siverio, Ana Estévez‐Braun, Ángel G. Ravelo, José Ramón Murguía, Abigail Rodrı́guez-Afonso,

Phytochemical compounds biological activities

Abstract Two novel tropolone derivatives 1 and 2 have been isolated from Goupia glabra . Their structures were determined by extensive 1D and 2D NMR spectroscopic studies. Compound 2 constitutes the first example isolated from a natural source of a Diels−Alder adduct between a tropolone and a naphthalene derivative. Compounds 1 and 2 exhibit significant toxicity towards a panel of DNA damage checkpoint defective yeast mutants, and behave as genotoxins, which highlights their potential to be used as anticancer drugs. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)