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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Efeito da composição do solvente sobre a estabilidade de proteínas em soluções aquosas

2006; Brazilian Chemical Society; Volume: 29; Issue: 3 Linguagem: Inglês

10.1590/s0100-40422006000300024

ISSN

1678-7064

Autores

Lúbia Cristina Fonseca, Natássia Caroline Resende Corrêa, Mário da Silva Garrote-Filho, Cleine Chagas da Cunha, Nilson Penha‐Silva,

Tópico(s)

Enzyme Catalysis and Immobilization

Resumo

AQUEOUS SOLUTIONS.A protein presents a native (N) macro state, which is functionally active, in equilibrium with the denatured (D) macro state, which is devoid of biological activity.An ensemble of microstates forms each macrostate.The denatured state comprises a greater ensemble of microstates than the native macrostate.The N-D equilibrium can be affected by several factors, that comprise the purity of the water, temperature, pH and solute concentration.This work discusses the influence of osmolytes and chaotropics on the N-D equilibrium in aqueous solutions.

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