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Evaluation of methods to estimate cigarette smoke uptake

1984; Wiley; Volume: 36; Issue: 6 Linguagem: Inglês

10.1038/clpt.1984.258

1532-6535

Robyn Hopkins, Lesley E Wood, Neil M. Sinclair,

Biochemical Analysis and Sensing Techniques

Clinical Pharmacology & TherapeuticsVolume 36, Issue 6 p. 788-795 Original Article Evaluation of methods to estimate cigarette smoke uptake R Hopkins PhD, Corresponding Author R Hopkins PhD Hazleton Laboratories Europe Ltd., Harrogate, and Carreras Rothmans Ltd., Research Division, BasildonHazleton Laboratories Europe Ltd., Otley Rd., Harrogate, North Yorkshire HG3 1PY, England.Search for more papers by this authorLesley E Wood MIBiol, Lesley E Wood MIBiol Hazleton Laboratories Europe Ltd., Harrogate, and Carreras Rothmans Ltd., Research Division, BasildonSearch for more papers by this authorN M Sinclair DPhil, N M Sinclair DPhil Hazleton Laboratories Europe Ltd., Harrogate, and Carreras Rothmans Ltd., Research Division, BasildonSearch for more papers by this author R Hopkins PhD, Corresponding Author R Hopkins PhD Hazleton Laboratories Europe Ltd., Harrogate, and Carreras Rothmans Ltd., Research Division, BasildonHazleton Laboratories Europe Ltd., Otley Rd., Harrogate, North Yorkshire HG3 1PY, England.Search for more papers by this authorLesley E Wood MIBiol, Lesley E Wood MIBiol Hazleton Laboratories Europe Ltd., Harrogate, and Carreras Rothmans Ltd., Research Division, BasildonSearch for more papers by this authorN M Sinclair DPhil, N M Sinclair DPhil Hazleton Laboratories Europe Ltd., Harrogate, and Carreras Rothmans Ltd., Research Division, BasildonSearch for more papers by this author First published: December 1984 https://doi.org/10.1038/clpt.1984.258Citations: 5AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Exposure to tobacco smoke is measured by a variety of invasive and noninvasive techniques. Our purpose was to examine how well some of these measures correlated when obtained simultaneously from the same subjects. On three occasions, six subjects were studied while they were smoking a single cigarette after 24 hr of abstinence. There were positive correlations between increases in heart rate and plasma nicotine concentrations and between percentage carboxyhemoglobin and exhaled carbon monoxide. Although residual cotinine was readily detected in samples of plasma before the subjects smoked, there was an increase in mean levels, with a peak approximately 1 hr after smoking. Urinary concentrations of nicotine, cotinine, and nicotine-1′-N-oxide and thiocyanate levels in plasma and saliva were essentially unchanged by smoking a single cigarette. Data on smoke generation and nicotine retention in cigarette butts correlated poorly with all other measures of smoke uptake. Clinical Pharmacology and Therapeutics (1984) 36, 788–795; doi:10.1038/clpt.1984.258 Citing Literature Volume36, Issue6December 1984Pages 788-795 RelatedInformation