Helium‐Neon laser irradiation inhibits the growth of kidney epithelial cells in culture
1990; Wiley; Volume: 10; Issue: 1 Linguagem: Inglês
10.1002/lsm.1900100110
ISSN1096-9101
AutoresAndreas J. Gross, Wolfgang Jelkmann,
Tópico(s)Cephalopods and Marine Biology
ResumoAbstract We have investigated the in vitro action of helium‐neon (He‐Ne) laser light on the cell cycle and the growth of rat kidney epithelial cell cultures. Dose‐response studies showed that repeated He‐Ne irradiation (dose rate 40 mW/cm 2 ) once a day in a dose range between 11.9 and 142 J/cm 2 significantly inhibited cell growth, while daily irradiation with 4.7 J/cm 2 had no effect. Microscopic examination of nuclear spreads revealed an increased number of cells in mitosis after a single irradiation with 142 J/cm 2 . These results support previous observations suggesting that laser light of low thermal energy interferes with cell cycling and may inhibit cell growth when irradiation is performed at doses of 11.9 J/cm 2 or more.
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