Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding
1995; Elsevier BV; Volume: 112; Issue: 2 Linguagem: Inglês
10.1016/0021-9150(94)05419-j
ISSN1879-1484
AutoresJ VANREE, Marion J. Gijbels, W VANDENBROEK, Marten H. Hofker, L.M. Havekes,
Tópico(s)Cancer, Lipids, and Metabolism
ResumoApolipoprotein (apo) E-deficient mice were fed a hypercholesterolemic diet for 14 weeks. Mean serum cholesterol levels rose to 37.5 mM. Upon complete necroscopy, massive xanthomatous lesions were noticed in various tissues, with a predilection for subcutaneous and peritendinous tissues, while control animals on the same diet (3.4 mM serum cholesterol) and apo E-deficient mice on a regular chow diet (20 mM serum cholesterol) did not show such lesions. Also, apo E3-Leiden transgenic mice fed a high fat diet, with 60 mM of serum cholesterol, did not exhibit any xanthomatosis. The xanthomatous lesions found in the Apoe knock-out mouse clearly differed in location from xanthomas previously found in low density lipoprotein receptor-deficient mice. We conclude that the lack of apo E results in atypical disseminated xanthomatosis, suggesting that apo E has an important role in determining the tissue distribution of cholesterol deposition.
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