Biomimetic Synthesis of Polycyclic Polyprenylated Acylphloroglucinol Natural Products Isolated from Hypericum papuanum
2010; American Chemical Society; Volume: 12; Issue: 15 Linguagem: Inglês
10.1021/ol101380a
ISSN1523-7060
AutoresJonathan H. George, Micha D. Hesse, Jack E. Baldwin, Robert M. Adlington,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoBiomimetic syntheses of three polycylic polyprenylated acylphloroglucinol natural products isolated from Hypericum papuanum, ialibinone A, ialibinone B, and hyperguinone B, have been accomplished by selective oxidative cyclizations of the proposed biosynthetic precursor 5, which was synthesized from phloroglucinol in three steps.
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