Primary hyperlipoproteinemia: The clinico-chemical classification of the most common types
1968; Elsevier BV; Volume: 19; Issue: 2 Linguagem: Inglês
10.1016/0009-8981(68)90325-2
ISSN1873-3492
AutoresCaitlin Hicks Pries, C.M. van Gent, H. Baes, M.K. Polano, H. Hulsman, A Querido,
Tópico(s)Cancer, Lipids, and Metabolism
ResumoIn this study, the classification according to Fredrickson of the most common types of primary hyperlipoproteinemia, i.e. types II, III and IV, was made on the basis of blood lipid composition, distribution of the lipids among the lipoproteins, and electropherographic analysis of the lipoproteins. The results permit the following conclusions: 1. The levels of total cholesterol (in mg/100 ml of plasma) cannot be used as a parameter for the discrimination of the different types. 2. The triglyceride levels can be used for the differentiation between type II and types III and IV. 3. The percentages of triglycerides and cholesterol of total lipids both serve, even more effectively, as parameters for the diagnosis of type II. 4. A clear distinction between types III and IV can be made from the distribution of the lipids as percentage of total lipids among pre-β1-lipoproteins, and β-lipoproteins. 5. Paper-electrophoresis of the serum lipoproteins, without further analytical data, permits differentiation between types II, III, and IV in only a limited percentage of the cases, but complete misinterpretation was also infrequent. 6. The excessive values for the levels of total lipids were found in the carbohydrate-induced cases of type IV. Preliminary ranges of total sterol, triglyceride, pre-β1-lipoprotein, and β-lipoprotein percentages serving as parameters for the classification of three types of hyperlipoproteinemia are presented.
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