Ketamine or Phencyclidine
1974; American Medical Association; Volume: 230; Issue: 6 Linguagem: Inglês
10.1001/jama.1974.03240060014014
ISSN1538-3598
Autores Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoTo the Editor.— In a recent issue (229:763, 1974), Shaffer describes a series of cases characterized by anesthesia, analgesia, nystagmus, dizziness, diplopia, visual distortions, and psychosis. These findings were attributed to ketamine, a derivative of phencyclidine. Phencyclidine is a major component of street drug preparations. 1 In one series, phencyclidine was detected in 184 of 237 street drug samples. 2 In liquid form, phencyclidine is sprayed on marihuana, parsley, oregano, or other plant leaves and sold as "angel dust." As a powder, it is marketed as phencyclidine or "peace pills." 3 It is frequently sold as LSD, mescaline, psilocybin, cocaine, 3, 4 - methylenedioxyamphetamine (MDA), tetrahydrocannabinol, and other more "attractive" drugs. Or it may be mixed with these agents. 2,3 Both ketamine and phencyclidine are sympathomimetic anesthetics. 4 However, phencyclidine is a much more potent hallucinogen. 4-6 The abuse of these compounds is a massive and generally unrecognized problem. Recently, 41
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