Produção Nacional
Revisado por pares
Population genetic analysis of insertion–deletion polymorphisms in a Brazilian population using the Investigator DIPplex kit
2015; Elsevier BV; Volume: 19; Linguagem: Inglês
10.1016/j.fsigen.2015.03.015
ISSN1878-0326
AutoresTeresinha de Jesus Brabo Ferreira Palha, Elzemar Martins Ribeiro Rodrigues, Giovanna C. Cavalcante, Andrea Rita Marrero, Ilíada Rainha de Souza, Clineu Julien Seki Uehara, Carlos Henrique Ares Silveira da Motta, Daniela Koshikene, Silva Da, Elizeu Fagundes de Carvalho, Gustavo Chemale, Jorge Marcelo de Freitas, Lídia Alexandre, Renato Teodoro Ferreira de Paranaíba, Mirella Perruccio Soler, Sidney Santos,
Tópico(s)Genetic diversity and population structure
ResumoThe aim of this study was to estimate the diversity of 30 insertion/deletion (INDEL) markers (Investigator® DIPplex kit) in a sample of 519 individuals from six Brazilian states and to evaluate their applicability in forensic genetics. All INDEL markers were found to be highly polymorphic in the Brazilian population and were in Hardy–Weinberg equilibrium. To determine their forensic suitability in the Brazilian population, the markers were evaluated for discrimination power, match probability and exclusion power. The combined discrimination power (CDP), combined match power (CMP) and combined power of exclusion (CPE) were higher than 0.999999, 3.4 × 10−13 and 0.9973, respectively. Further comparison of 29 worldwide populations revealed significant genetic differences between continental populations and a closer relationship between the Brazilian and European populations.
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