Portal de Periódicos da CAPES

Device-based controlled local delivery of anastrozol into peritoneal cavity: in vitro and in vivo evaluation

2014; Elsevier BV; Volume: 24; Issue: 2 Linguagem: Inglês

10.1016/s1773-2247(14)50032-9

2588-8943

Fabrice Krier, Raphaël Riva, Sylvie Defrère, Mélanie Mestdagt, Anne Van Langendonckt, Pierre Drion, Jean‐Paul Dehoux, J. Donnez, Jean‐Michel Foidart, Christine Jérôme, Brigitte Évrard,

Anesthesia and Pain Management

Local treatment using drug loaded implants allows decreasing seric concentrations of the active ingredient with the purpose of limiting side effects and reaching perfect observance. Nowadays, some diseases are already treated with implants, but generally, by subcutaneous or intra vaginal implantation. In this work, a new implant device dedicated to the intra-peritoneal cavity was developed. For this purpose, a core-mem-brane polymer implant was selected. We propose an original method to determine the most appropriate membrane to control the release based on the use of Franz cells. The ability of the implant to release a constant quantity of an active ingredient will be assessed by testing implants in vitro. Finally, intra peritoneal cavity and subcutaneous in vivo implantation has been achieved in order to confirm the controlled and local release of the active ingredient.