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Cytochemical study of prolactin-releasing peptide (PrRP) in the rat brain

1999; Lippincott Williams & Wilkins; Volume: 10; Issue: 8 Linguagem: Inglês

10.1097/00001756-199906030-00016

1473-558X

Norio Iijima, Yuko Kataoka, Kenshi Kakihara, Hitoshi Bamba, Y. Tamada, Seiji Hayashi, Tomoyuki Matsuda, Masaki Tanaka, Hideo Honjyo, Masaki Hosoya, Shuji Hinuma, Yasuhiko Ibata,

Neuropeptides and Animal Physiology

STRONG positive signals for PrRP mRNA and PrRP-like immunoreactivity (PrRP-LI) were detected in the nucleus of the solitary tract and ventral and lateral reticular formation of the caudal medulla oblongata. Weak mRNA signals and immunoreactivity were seen scattered from the hypothalamic dorsomedial nucleus (DMH) to ventromedial nucleus (VMH). Nerve processes and terminals with PrRP-LI were detected from the septal region to the diencephalon. These nerve processes were also clearly visible around capillary walls and in the vicinity of the ependymal cells of the third and lateral ventricles. These observations suggested that PrRP might be secreted into the systemic circulation and cerebrospinal fluid and may play functional roles other than in the release of prolactin from the anterior pituitary.