The Composition of the Ceramides from Human Stratum Corneum and from Comedones
1985; Elsevier BV; Volume: 84; Issue: 5 Linguagem: Inglês
10.1111/1523-1747.ep12265510
ISSN1523-1747
AutoresPhilip W. Wertz, Marion C. Miethke, Sherri A. Long, John S. Strauss, Donald T. Downing,
Tópico(s)Circadian rhythm and melatonin
ResumoHuman epidermal surface lipids were collected by an ethanol wash and the ceramides were quantified by thin-layer chromatography-photodensitometry. Six ceramide fractions were isolated and the structural components of each were analyzed in detail. The most unusual of the epidermal ceramides contained a sphingosine base with amide-linked 30- and 32-carbon omega-hydroxyacids and an ester-linked nonhydroxyacid, 41% of which was linoleic acid. The proportion of linoleic acid in the analogous ceramide from comedones was 6%. This supports the hypothesis that a localized insufficiency of linoleic acid in the follicular epithelium is an etiologic factor in comedogenesis.
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