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Synthesis of a key intermediate of levofloxacin via enantioselective hydrogenation catalyzed by iridium(I) complexes

1998; Elsevier BV; Volume: 9; Issue: 15 Linguagem: Inglês

10.1016/s0957-4166(98)00276-6

1362-511X

Koji Satoh, Minako Inenaga, Kazuaki Kanai,

Drug Transport and Resistance Mechanisms

The key intermediate 2 for the antibacterial agent levofloxacin 1 was prepared by utilizing catalytic asymmetric hydrogenation of the cyclic imine 3 with the iridium(I) complex of (2S,4S)-BPPM in the presence of bismuth(III) iodide.