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Pulmonary Hemorrhage and Glomerulonephritis

1965; American College of Physicians; Volume: 62; Issue: 5 Linguagem: Inglês

10.7326/0003-4819-62-5-920

1539-3704

Donald A. Duncan,

Complement system in diseases

Article1 May 1965Pulmonary Hemorrhage and GlomerulonephritisReport of Six Cases and Study of the Renal Lesion by the Fluorescent Antibody Technique and Electron MicroscopyDONALD A. DUNCAN, M.D., KEITH N. DRUMMOND, M.D., ALFRED F. MICHAEL, M.D., ROBERT L. VERNIER, M.D.DONALD A. DUNCAN, M.D.Search for more papers by this author, KEITH N. DRUMMOND, M.D.Search for more papers by this author, ALFRED F. MICHAEL, M.D.Search for more papers by this author, ROBERT L. VERNIER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-920 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeveral reports of diffuse pulmonary hemorrhage associated with glomerulonephritis have appeared in recent years. Ernest Goodpasture (1) appears to have described the first case in 1919. The patient was an 18-year-old male with "typical influenza" at the height of the 1918 to 1919 influenza pandemic. After initial improvement he developed persistent hemoptysis, anemia, and a bilateral pulmonary infiltrate. The total illness lasted 6 weeks. Autopsy revealed extensive intra-alveolar hemorrhage, scattered alveolar necrosis and, unexpectedly, a proliferative glomerulonephritis.Since then at least 92 additional cases (2-10) have been described (see the review by Benoit and associates (2) for references to the...References1. GOODPASTURE EW: The significance of certain pulmonary lesions in relation to the etiology of influenza. Amer. J. Med. Sci. 158: 863, 1919. CrossrefGoogle Scholar2. BENOITRULONTHEILDOOLANWATTEN FLDBGBPDRH: Goodpasture's syndrome. A clinicopathologic entity. Amer. J. Med. 37: 424, 1964. CrossrefMedlineGoogle Scholar3. MCCAUGHEYTHOMAS WTBJ: Pulmonary hemorrhage and glomerulonephritis. Amer. J. Clin. Path. 38: 577, 1962. CrossrefMedlineGoogle Scholar4. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnesotaFrom the Departments of Medicine and Pediatrics, University of Minnesota Hospitals, Minneapolis, Minn.These studies were supported by grants HE-05662 and AI-02618 from the U. S. Public Health Service, Bethesda, Md., and by grants from the Minnesota Heart Association, the American Heart Association, and the St. Louis Park Medical Center Research Foundation.Requests for reprints should be addressed to Donald A. Duncan, M. D., St. Louis Park Medical Center, 4959 Excelsior Boulevard, Minneapolis, Minnesota 55416. 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