A genetic view of iron homeostasis
2002; Elsevier BV; Volume: 39; Issue: 4 Linguagem: Inglês
10.1053/shem.2002.35632
ISSN1532-8686
Autores Tópico(s)Trace Elements in Health
ResumoInherited disorders of iron metabolism are invariably disorders of iron balance or distribution. This review describes the proteins known to be involved in establishing and maintaining iron balance, and discusses regulation of iron homeostasis in the context of three cell types: intestinal enterocytes, reticuloendothelial macrophages, and hepatocytes. It emphasizes information gleaned from the use of genetic analyses, particularly in mice, and poses new questions to help advance our understanding of iron balance. Semin Hematol 39:227-234. Copyright 2002, Elsevier Science (USA). All rights reserved.
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