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Autoregulation of endothelin-1 secretion by cultured human keratinocytes via the endothelin B receptor

1994; Elsevier BV; Volume: 1224; Issue: 3 Linguagem: Inglês

10.1016/0167-4889(94)90282-8

1879-2596

Joseph Yohn, Christopher M. Smith, Troy Stevens, Joseph G. Morelli, Libby R. Shurnas, Sandra J. Walchak, Talia A. Hoffman, Kim K. Kelley, Antonio Escobedo-Morse, Masashi Yanagisawa, Madeleine Kane, Martin R. Zamora,

Mast cells and histamine

We investigated endothelin-1 (ET-1) receptor expression on normal human keratinocytes (HK). We show that HK express the ETB receptor isoform and respond to ET-1 with a 2.7-fold increase in intracellular free calcium. HK did not respond to ET-1 with increased proliferation; however, 30 nM ET-1 caused a 51.7% decrease in ET-1 accumulation in HK-conditioned medium. We propose that HK ET-1 receptors function in autocrine regulation of ET-1 secretion.