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CTLA‐4 gene polymorphisms and natural soluble CTLA‐4 protein in psoriasis vulgaris

2006; Wiley; Volume: 33; Issue: 3 Linguagem: Inglês

10.1111/j.1744-313x.2006.00600.x

1744-313X

Wioleta Łuszczek, Wioletta Kubicka, Monika Jasek, Emine Baran, M Cisło, Piotr Nockowski, M. Łuczywo‐Rudy, Andrzej Wiśniewski, Izabela Nowak, Piotr Kuśnierczyk,

Immunodeficiency and Autoimmune Disorders

Summary CTLA‐4 molecule is an important inhibitor of T‐lymphocyte activation. Several single nucleotide polymorphisms (SNPs) in the CTLA‐4 gene were found, and their associations with many human diseases were described. So far, however, such studies have not been performed in psoriasis vulgaris in Caucasoids. Therefore, we examined the distribution of three CTLA‐4 SNPs: −1147C/T, −318C/T and +49 A/G in 116 patients with psoriasis vulgaris and 123 healthy blood donors using the polymerase chain reaction–restriction fragment length polymorphism method. For all three SNPs, the frequencies of alleles, genotypes and three‐point haplotypes were very similar in patients and controls, suggesting no contribution of these genetic variants to psoriasis.