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Further studies of competition of antigens. I. Variation in immunosuppression induced by alterations of dosage, route of injection, nature of antigen, and immunological status of host

1971; Canadian Science Publishing; Volume: 17; Issue: 6 Linguagem: Inglês

10.1139/m71-127

1480-3275

David Eidinger, Hugh F. Pross, Robert S. Kerbel, Malcolm G. Baines, Aleksander Ackerman, Salahuddin A. Khan,

Immune Response and Inflammation

Several characteristics of antigenic competition were studied in mice using various pairs of antigens administered in sequence. Enhanced immunosuppression of the response to the second antigen was obtained by increasing the dose of the initial antigen relative to the dose of the test antigen. Diminished immunosuppression was elicited when the dose of the second antigen was increased to near maximum levels, corresponding to the plateau of immune responsiveness to this antigen when it was administered in equivalent dosage to normal control groups of animals. Induction of a primary immune response to the initial antigen was a more effective immunosuppressant than was induction of a secondary immune response to an equivalent dose of the same antigen. Antigenic competition was manifested when antigen was administered in differing sites in the animal such as in separate footpads. Administration of the antigens in the same site did not invariably result in antigenic competition, since a combination of two intraperitoneal injections of unrelated antigens in sequence was not associated with immunosuppression of response to the test antigen. Immunosuppression by antigenic competition did not alter the affinity of the antibody product to the test antigen.