Genetics and Expression of the Carbapenem-Hydrolyzing Oxacillinase Gene bla OXA-23 in Acinetobacter baumannii
2007; American Society for Microbiology; Volume: 51; Issue: 4 Linguagem: Inglês
10.1128/aac.01132-06
ISSN1098-6596
AutoresStéphane Corvec, Laurent Poirel, Thierry Naas, H Drugeon, Patrice Nordmann,
Tópico(s)Bacterial biofilms and quorum sensing
ResumoThe genetic structures surrounding the plasmid-carried blaOXA-23 oxacillinase gene, encoding resistance to carbapenems, were studied in Acinetobacter baumannii. ISAba1 and the novel element ISAba4 were detected upstream of the blaOXA-23 gene, providing promoter sequences for its expression. These insertion elements were likely involved in transposition processes at the origin of acquisition of this beta-lactamase gene.
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