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Systemic Mycoses—Primary Pathogenic Fungi

1973; Elsevier BV; Volume: 15; Issue: 6 Linguagem: Inglês

10.1016/s0003-4975(10)65361-1

1552-6259

Maruf A. Razzuk, Harold C. Urschel, Donald L. Paulson,

Fungal Infections and Studies

Systemic mycoses are caused by certain species of Deuteromycetes and Schizomycetes.The primary infection occurs in the lung and is acquired by inhaling spores or hyphae.The severity of the infection varies from a subclinical type to a disseminated and often fatal disease.The clinical diagnosis of the infection must be substantiated by morphological demonstration of the fungus in tissues or culture.The mode of therapy is determined by the nature and stage of the infection.rimary systemic mycotic infections are caused chiefly by species of Deuteromycetes and Schizomycetes.These commonly include Histo-P plasma capsulatum, Coccidioides immitis, Cryptococcus neoformans, Blastomyces dermatitidis, Actinomyces israelii, and Nocardia asteroides.The Schizomycetes, namely A. israelii and N. asteroides, are classified as higher bacteria, and only by tradition and habit are infections with these organisms discussed as mycotic infections.-Thesefungi are worldwide in distribution except for C. immitis, which is fairly well limited to American countries, and B. dermatitidis, which is limited to North and Central America.With the exception of A .israelii, which maintains a saprophytic growth in the normal oral cavity, these fungi are free-living saprophytes in man's environment.Frequently they are primary pathogens and constitute a great threat to life because of their potential to cause generalized or systemic infection.The majority of the primary infections occur in the lung.The pulmonary lesions occur most frequently in hilar and basal areas, although