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Experimental food allergy leads to adipose tissue inflammation, systemic metabolic alterations and weight loss in mice

2011; Elsevier BV; Volume: 270; Issue: 2 Linguagem: Inglês

10.1016/j.cellimm.2011.05.008

1090-2163

Luana Pereira Antunes Dourado, Maria de Lourdes Meirelles Noviello, Débora Moreira Alvarenga, Zélia Menezes, Denise Perez, Nathália Vieira Batista, Gustavo Batista Menezes, Adaliene Versiani Matos Ferreira, Danielle da Glória de Souza, Denise Carmona Cara,

Regulation of Appetite and Obesity

To investigate the consequences of food allergy in adipose tissue and metabolism, we used a murine model in which mice have been sensitized subcutaneously with ovalbumin and further received antigen-containing diet. Allergic mice presented a significant weight loss 7 days after oral challenge with a concomitant decrease in epididymal adipose tissue mass. This decrease was associated with increased lipolysis and local inflammation. In adipose tissue of allergic mice there were increased leukocyte rolling and adhesion in the microvasculature, increased number of leukocytes in the tissue, especially macrophages (F4/80+ cells) and increased pro-inflammatory cytokines levels, including TNF-α, IL-6 and CCL2. In addition, we observed low serum concentrations of triglyceride, glucose, total cholesterol and free fatty acids in the allergic mice. Our results suggest that the induction of food allergy in mice leads to adipose tissue inflammation and systemic metabolic alterations that contribute to the weight loss observed.