A Pathogenetic Mechanism in Lung Fibrosis
1980; Elsevier BV; Volume: 78; Issue: 2 Linguagem: Inglês
10.1378/chest.78.2_supplement.395
ISSN1931-3543
AutoresHanspeter Witschi, Wanda M. Haschek, Kathleen Meyer, Robert L. Ullrich, Walden E. Dalbey,
Tópico(s)Pesticide Exposure and Toxicity
ResumoPathogenetic features common to many forms of interstitial pulmonary fibrosis are a chronic alveolitis, changes in the cellular composition of the alveolar zone, and derangement of the interstitial collagen. Fibrosis often appears to develop as a common sequel to injury when normal tissue repair fails to take place. 1 Fulmer JD Crystal RG The biochemical basis of pulmonary function. in: Crystal RG The Biochemical Basis of Pulmonary Function. Marcel Dekker, New York1976 Google Scholar It may be precipitated and sustained by exposure to a single etiologic agent such as inhaled particles of silica or irradiation of the thorax. In other forms, such as idiopathic pulmonary fibrosis, the etiologic agent remains unknown. Recently we suggested that pulmonary fibrosis could develop following the interaction between an agent reaching the lung via the bloodstream and a toxic inhalant. 2 Haschek WM Witschi HP Pulmonary fibrosis—a possible mechanism. Toxicol Appl Pharmacol. 1979; 51: 475-487 Crossref PubMed Scopus (162) Google Scholar This speculation was based upon the following experimental observations.
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